Dr. Popham began the private practice of ophthalmic plastic and reconstructive surgery in Denver after completing his fellowship training at Harvard Medical School in Boston. Prior to his advanced training in oculoplastic surgery at Harvard Medical School, Dr. Popham completed residency training in the microsurgical techniques of ophthalmic and intraocular surgery at Texas A&M University Medical School. Dr. Popham is board certified by the American Board of Ophthalmology and is a Fellow of the American College of Surgeons. He is also a member of the American Society of Facial Plastic and Reconstructive Surgery and has served for over a decade as the Chairman of the Department of Ophthalmology at the largest hospital in Colorado. He teaches ophthalmic plastic surgery to physicians in training and has academic appointments as assistant clinical professor of ophthalmology and clinical instructor in otolaryngology at the University of Colorado Health Sciences Center in Denver. Dr. Popham has written numerous scientific articles published in medical journals and has written several book chapters related to oculoplastic surgery. He recently co-authored the primary book used as a reference by physicians in training worldwide, Ophthalmic Plastic, Orbital, and Lacrimal Surgery, published by the American Academy of Ophthalmology. He has lectured nationally and internationally on topics related to cosmetic and reconstructive oculoplastic surgery.

Based on the votes of his colleagues, Dr. Popham has been recognized as Colorado's best plastic surgery - blepharoplasty surgeon in Denver's 5280 Magazine on five separate occasions. He has also been named in 5280 Magazine as one of the top doctors in Denver in the use of cosmetic Botox. He is a member of the National Educational Faculty for Botox Cosmetic. He is a national training physician for Sanofi-Aventis Pharmaceutical's product, Sculptra. He has been recognized as one of the Best Doctors in America in the years 2000, 2001, 2002, 2003 and 2004, and 2007. Dr. Popham is the recipient of the Achievement Award of the American Academy of Ophthalmology and the Outstanding Young Ophthalmologist Award of the Colorado Society of Eye Physicians and Surgeons.

Dr. Popham has pioneered a variety of minimally invasive, small incision or no incision surgical techniques related to eyelid, lacrimal, and orbital surgery, including endoscopic midface lifting, endoscopic balloon-assisted tear drain surgery, and laser blepharoplasty. His primary medical interests are related to cosmetic and reconstructive surgery of the facial structures around the eyes, particularly those that minimize visible scarring and recovery time for his patients.

Dr. Popham is also committed to serving the medical needs of the poor. As a Director of the non-profit organization, About Face Foundation, he leads a team of physicians and nurses annually to Ho Chi Minh City, Vietnam where American surgeons collaborate with Vietnamese surgeons to perform facial reconstructive surgeries for indigent Vietnamese children.